IDH mutations associated impact on related cancer epidemiology and subsequent effect toward HIF-1α

被引:18
作者
Semukunzi, Herve [1 ]
Roy, Debmalya [1 ]
Li, Hongyang [2 ]
Khan, Ghulam Jilany [1 ]
Lyu, Xiaodan [1 ]
Yuan, Shengtao [1 ]
Lin, Sensen [2 ]
机构
[1] China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Jiangsu Ctr Pharmacodynam Res & Evaluat, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China
关键词
(D)-2-hydroxyglutarate (D-2-HG); Isocitrate dehydrogenase (IDH); Epidemiology; Oncogenicity; Hypoxia inducible factor (HIF); ISOCITRATE DEHYDROGENASE 1; MYELODYSPLASTIC SYNDROMES; GLIOMA; LEUKEMIA; GROWTH; D-2-HYDROXYGLUTARATE; ONCOMETABOLITE; METHYLATION; PHENOTYPE; SURVIVAL;
D O I
10.1016/j.biopha.2017.02.083
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Particular mutations in the isocitrate dehydrogenase gene (IDH) were discovered in several gliomas citing astrocytoma, oligodendroglioma, and glioblastoma multiform, but also in leukemia; these mutations were discovered in nearly all cases of secondary glioblastomas, they evolve from lower-grade gliomas, but are limited in primary high-grade glioblastoma multiform. These mutations distinctively produce (D)-2-hydroxyglutarate (D-2-HG) from alpha-ketoglutarate (alpha-KG). (D)-2-hydroxyglutarate is accumulated to very high concentrations which inhibit the function of enzymes that are dependent on alpha-ketoglutarate. This modification leads to a hyper-methylated state of DNA and histones, resulting in different gene expression that can activate oncogenes and inactivate tumor-suppressor genes. In our work we review the impact of the mutations that occur in IDH genes, we focus on their impact on distribution in cancer. As IDH mutations appear in many different conditions we expose the extent of IDH mutations and derivate their impact on cancer prognosis, diagnosis, and even their oncogenicity, we will also link their impact to HIF-1 alpha and derivate some target and finally, we present some of the therapeutics under research and out on market. (C) 2017 Published by Elsevier Masson SAS.
引用
收藏
页码:805 / 811
页数:7
相关论文
共 63 条
[1]   Rare insights into cancer biology [J].
Adam, J. ;
Yang, M. ;
Soga, T. ;
Pollard, P. J. .
ONCOGENE, 2014, 33 (20) :2547-2556
[2]   Comparative study of IDH1 mutations in gliomas by immunohistochemistry and DNA sequencing [J].
Agarwal, Shipra ;
Sharma, Mehar Chand ;
Jha, Prerana ;
Pathak, Pankaj ;
Suri, Vaishali ;
Sarkar, Chitra ;
Chosdol, Kunzang ;
Suri, Ashish ;
Kale, Shashank Sharad ;
Mahapatra, Ashok Kumar ;
Jha, Pankaj .
NEURO-ONCOLOGY, 2013, 15 (06) :718-726
[3]   Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment [J].
Andersen, Anne Poder ;
Moreira, Jose M. A. ;
Pedersen, Stine Falsig .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2014, 369 (1638)
[4]   Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate [J].
Andronesi, Ovidiu C. ;
Rapalino, Otto ;
Gerstner, Elizabeth ;
Chi, Andrew ;
Batchelor, Tracy T. ;
Cahil, Dan P. ;
Sorensen, A. Gregory ;
Rosen, Bruce R. .
JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (09) :3659-3663
[5]   Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping [J].
Borger, Darrell R. ;
Tanabe, Kenneth K. ;
Fan, Kenneth C. ;
Lopez, Hector U. ;
Fantin, Valeria R. ;
Straley, Kimberly S. ;
Schenkein, David P. ;
Hezel, Aram F. ;
Ancukiewicz, Marek ;
Liebman, Hannah M. ;
Kwak, Eunice L. ;
Clark, Jeffrey W. ;
Ryan, David P. ;
Deshpande, Vikram ;
Dias-Santagata, Dora ;
Ellisen, Leif W. ;
Zhu, Andrew X. ;
Iafrate, A. John .
ONCOLOGIST, 2012, 17 (01) :72-79
[6]   IDH1 and IDH2 mutations in myeloid neoplasms - Novel paradigms and clinical implications [J].
Cazzola, Mario .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 (10) :1623-1627
[7]   Making sense of cancer genomic data [J].
Chin, Lynda ;
Hahn, William C. ;
Getz, Gad ;
Meyerson, Matthew .
GENES & DEVELOPMENT, 2011, 25 (06) :534-555
[8]   DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma [J].
Christensen, Brock C. ;
Smith, Ashley A. ;
Zheng, Shichun ;
Koestler, Devin C. ;
Houseman, E. Andres ;
Marsit, Carmen J. ;
Wiemels, Joseph L. ;
Nelson, Heather H. ;
Karagas, Margaret R. ;
Wrensch, Margaret R. ;
Kelsey, Karl T. ;
Wiencke, John K. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (02) :143-153
[9]   The role of microRNAs in hematopoietic stem cell and leukemic stem cell function [J].
Chung, Stephen S. ;
Hu, Wenhuo ;
Park, Christopher Y. .
THERAPEUTIC ADVANCES IN HEMATOLOGY, 2011, 2 (05) :317-334
[10]   IDH1 and IDH2 Mutations in Gliomas [J].
Cohen, Adam L. ;
Holmen, Sheri L. ;
Colman, Howard .
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2013, 13 (05)