The testicular protective effects of standardised hydroalcoholic extract of Ziziphus jujuba Mill against adriamycin-induced toxicity

被引:4
作者
Mohebbati, Reza [1 ]
Kamkar-Del, Yasamin [2 ]
Shahraki, Samira [3 ]
Khajavi Rad, Abolfazl [2 ]
机构
[1] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran
[2] Mashhad Univ Med Sci, Dept Physiol, Fac Med, Mashhad, Razavi Khorasan, Iran
[3] Zahedan Univ Med Sci, Sch Med, Dept Physiol, Zahedan, Iran
关键词
adriamycin; oxidative stress; spermatozoa; testis; Ziziphus jujuba; ZATARIA-MULTIFLORA EXTRACT; OXIDATIVE STRESS; CARDIOVASCULAR-RESPONSES; ASCORBIC-ACID; FRUIT EXTRACT; DNA-DAMAGE; VITAMIN-C; DOXORUBICIN; APOPTOSIS; CYCLOPHOSPHAMIDE;
D O I
10.1111/and.13974
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
In this study, because of the anti-inflammatory and antioxidant effect of the Ziziphus jujuba (ZJ), we assessed the protective properties of the ZJ extract against testis toxicity caused by Adriamycin in the rat. Twenty rats were grouped into (a) control, (b) Adriamycin, (c) ZJ group and (d) treatment group in which Adriamycin was administrated and the ZJ hydroalcoholic extract was used for three weeks. On the 21st day, two testes were removed to determine the oxidation markers and pathological evaluation. The levels of sex hormones were determined. Epididymis also was crushed, and its spermatozoa were evaluated as concentration, motility and normality. Adriamycin increased oxidative stress markers as well as Luteinising hormone, and follicle-stimulating hormone and decreased testosterone levels compared to control. In the treated group, the levels of the above markers improved. The decreased number and motility of spermatozoa in treatment group increased, and the increased rate of abnormal spermatozoa in this group decreased. Pathological evaluations also show the healing process of damaged testicular tissue in the group receiving the ZJ extract. The ZJ extract relatively improves oxidative stress, sperm characteristics, hormonal alternation and pathological changes. These findings reveal the probable role of ZJ effective compounds in repairing tissue damage.
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页数:12
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