Wound Closure Outcomes Suggest Clinical Equivalency Between Lyopreserved and Cryopreserved Placental Membranes Containing Viable Cells

被引:14
作者
Ananian, Charles E. [1 ]
Davis, R. Daniel [2 ]
Johnson, Eric L. [3 ]
Regulski, Matthew J. [4 ]
Reyzelman, Alexander M. [5 ]
Saunders, Molly C. [6 ]
Danilkovitch, Alla [6 ]
机构
[1] New Hope Podiatry, 3616 E 1st St, Los Angeles, CA 90063 USA
[2] Family Podiatry Ctr, Bridgeport, CT USA
[3] Bozeman Hlth Deaconess Hosp, Wound & Hyperbar Ctr, Bozeman, MT USA
[4] Ocean Cty Foot & Ankle Surg Associates PC, Forked River, NJ USA
[5] Samuel Merritt Univ, Calif Sch Podiatr Med, Oakland, CA USA
[6] Osiris Therapeut Inc, Columbia, MD USA
关键词
viable; lyopreserved; placental membrane; nonhealing; wound; AMNIOTIC MEMBRANE; FOOT ULCERS; PRODUCTS; MATRIX;
D O I
10.1089/wound.2019.1028
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Objective: To evaluate the clinical outcomes of lyopreserved placental membrane containing viable cells (vLPM) in the treatment of nonhealing wounds of various etiologies, and to compare them to those previously reported for cryopreserved placental membrane containing viable cells (vCPM). Approach: Patients with nonhealing wounds who qualified to receive advanced wound therapies were consecutively enrolled and treated weekly with vLPM plus standard of care (SOC) at five centers. Data were de-identified and retrospectively analyzed. Outcomes included closure, time to closure, number of vLPM applications, and adverse events (AEs). Results: Seventy-eight patients with 98 wounds (41 diabetic foot ulcers [DFUs], 19 venous leg ulcers [VLUs], 10 surgical, and 28 others) with an average size of 13.3 cm(2) and 8.7 months duration were treated. Fifty-eight of the 98 wounds (59.2%) achieved complete closure with median time to closure of 63 days and 6 vLPM applications. The closure by wound etiology was 63% for DFUs, 47% for VLUs, 70% for surgical wounds, and 57% for other types of wounds. Similar closure rates have been previously demonstrated for vCPM. Wound duration was the main predictor of closure: 65.8% versus 30.0% (p = 0.004) closure was achieved for wounds of <= 12 and >12 months duration, respectively. There were no AEs related to vLPM application. Innovation: This is the first multicenter case series evaluating the clinical outcomes of vLPM in a real-world setting. Conclusion: These results support clinical equivalency between the two placental membrane formulations with the added convenience of room-temperature storage for vLPM, allowing it to be used in any wound-care setting.
引用
收藏
页码:546 / 554
页数:9
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