Anthraquinones related to rhein inhibit glucose uptake into chondrocytes. A mechanism for anti-osteoarthritis drugs?

被引：4

作者：

Carney, SL

Broadmore, RJ

Tomlinson, R

Kingston, A

Gallagher, PT

Owton, WM

Miles, MV

Brunavs, M

Smith, CW

Hicks, TA

Dobson, DR

Steggles, DJ

Ambler, SJ

Halliday, KA

机构：

[1] Lilly Research Centre Ltd., Windlesham, Surrey, GU20 6PH, Erl Wood Manor

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(97)00102-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Rhein has been shown to inhibit the uptake of glucose into Ehrlich Ascites tumor cells. In this paper we show that a wide range of anthraquinones related to rhein can also inhibit glucose uptake into chondrocytes, many significantly more than the parent molecule. (C) 1997 Elsevier Science Ltd.

引用

页码：817 / 822

页数：6

共 15 条

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BIRD TA, 1990, J BIOL CHEM, V265, P13578

[2]

CARNEY S L, 1984, Journal of Orthopaedic Research, V2, P201, DOI 10.1002/jor.1100020301

[3] RHEIN INHIBITS GLUCOSE-UPTAKE IN EHRLICH ASCITES TUMOR-CELLS BY ALTERATION OF MEMBRANE-ASSOCIATED FUNCTIONS [J].