Neuroprotective Effect of Fagopyrum dibotrys Extract against Alzheimer's Disease

Accumulated evidence suggests that polyphenolic antioxidants present in herbs play important roles in prevention of AD; the molecular mechanisms behind neuroprotective actions rely on the phenols through different effects on the amyloid-aggregation pathway. Fagopyrum dibotrys is a traditional herbal medicine which contains high quantity phenols. In present study, we investigate the beneficial pharmacological actions of Fagopyrum dibotrys extract in the APP/PS1 transgenic mouse mode; meanwhile, effects of the FDE on the fibrillation and cytotoxicity of A beta peptide were evaluated in vitro. After 9-month treatment, FDE exhibited multifunctional properties on A beta-related pathologies, which cleaned A beta deposits in the brain and decreased A beta burden in the plasma, inhibited microhaemorrhage, and reduced reactive microglia in APP/PSI transgenic mice and also promoted A beta fibrils disaggregation and inhibited neurotoxicity induced by A beta in SH-SY5Y cells. These results highlighted that FDE is an AD type pathology modulator with therapeutic potential against AD.