Correlation of glioma proliferation assessed by flow cytometry with 99mTc-Tetrofosmin SPELT uptake

被引：22

作者：

Alexiou, George A. ^{[1
]}

Tsiouris, Spyridon ^{[2
]}

Vartholomatos, George ^{[3
]}

Fotakopoulos, George ^{[1
]}

Papadopoulos, Athanasios ^{[2
]}

Kyritsis, Athanasios P. ^{[4
]}

Voulgaris, Spyridon ^{[1
]}

Fotopoulos, Andreas D. ^{[2
]}

机构：

[1] Univ Hosp, Dept Neurosurg, Ioannina, Greece

[2] Univ Hosp, Dept Nucl Med, Ioannina, Greece

[3] Univ Hosp, Haematol Lab, Mol Biol Unit, Ioannina, Greece

[4] Univ Hosp, Inst Neurosurg, Dept Neurol, Ioannina, Greece

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2009年 / 111卷 / 10期

关键词：

Glioma; Flow cytometry; Tc-99m-Tetrofosmin SPECT; CELL NUCLEAR ANTIGEN; BRAIN-TUMORS; DNA-CONTENT; TL-201; SPECT; TC-99M-SESTAMIBI; GLIOBLASTOMA; TC-99M-MIBI; TETROFOSMIN; GRADE;

D O I：

10.1016/j.clineuro.2009.08.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: Brain single-photon emission computed tomography (SPECT) has been proposed as a potentially useful modality for the metabolic assessment of various brain tumors. Material and methods: In a 10-patient prospective pilot study we evaluated whether Tc-99m-Tetrofosmin (Tc-99m-TF) uptake correlates with glioma proliferative activity assessed by flow cytometric analysis. Tc-99m-TF brain SPECT was performed shortly before surgical tumor excision. Results: Eight patients were diagnosed with glioblastoma multiform and 2 with anaplastic astrocytoma. All tumors were aneuploid. We found a significant positive linear correlation between 99mTc-TF uptake and percentage of tumor cells on the S-phase of the cell cycle (r=0.92, P=0.001). Conclusion: Initial evidence suggests that 99mTc-TF could provide a non-invasive indicator of glioma proliferative activity. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：808 / 811

页数：4

共 25 条

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