Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient

被引：220

作者：

Baang, Ji Hoon ^{[1
]}

Smith, Christopher ^{[2
]}

Mirabelli, Carmen ^{[3
]}

Valesano, Andrew L. ^{[1
,3
]}

Manthei, David M. ^{[4
]}

Bachman, Michael A. ^{[4
]}

Wobus, Christiane E. ^{[3
]}

Adams, Michael ^{[2
]}

Washer, Laraine ^{[1
]}

Martin, Emily T. ^{[5
]}

Lauring, Adam S. ^{[1
,3
]}

机构：

[1] Univ Michigan, Div Infect Dis, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Div Hosp Med, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 223卷 / 01期

关键词：

SARS-CoV-2; COVID-19; immunocompromise; evolution; antibody;

D O I：

10.1093/infdis/jiaa666

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe a case of chronic coronavirus disease 2019 (COVID-19) in a patient with lymphoma and associated B-cell immunodeficiency. Viral cultures and sequence analysis demonstrate ongoing replication of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for at least 119 days. The patient had 3 admissions related to COVID-19 over a 4-month period and was treated twice with remdesivir and convalescent plasma with resolution of symptoms. The patient's lack of seroconversion and prolonged course illustrate the importance of humoral immunity in resolving SARS-CoV-2 infection. This case highlights challenges in managing immunocompromised hosts, who may act as persistent shedders and sources of transmission.

引用

页码：23 / 27

页数：5

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