The role of angiotensin II in hypertension due to adenosine receptors blockade

被引:17
作者
Morato, M
Sousa, T
Guimaraes, S
Moura, D
Albino-Teixeira, A
机构
[1] Univ Porto, Inst Pharmacol & Therapeut, Fac Med Porto, P-4200319 Oporto, Portugal
[2] Univ Porto, IBMC, P-4200319 Oporto, Portugal
关键词
adenosine receptors blockade; hypertension; angiotensin II; vascular reactivity;
D O I
10.1016/S0014-2999(02)02587-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The renin-angiotensin system may be involved in hypertension induced by adenosine receptors blockade with 1,3-dipropyl-8-sulfophenylxanthine (DPSPX). Contractions of the mesenteric vasculature to angiotensin II, noradrenaline and potassium chloride were studied in DPSPX-induced hypertension. Male Wistar rats received infusions of saline or DPSPX (90 mug kg(-1) h(-1), i.p.) for 3 or 7 days. Blood pressure was determined by the tail-cuff method. On days 3 or 14, concentration-response curves were obtained on mesenteric arteries and veins. Plasma angiotensin II levels, measured by radioimmunoassay, were higher in DPSPX-hypertensive rats. The maximum contractile effect of angiotensin II was lower in vessels from DPSPX-hypertensive rats while that for noradrenaline was higher. Potassium chloride-induced contractions were larger in veins from DPSPX-hypertensive rats but similar in arteries, when compared with control rats. We conclude that raised angiotensin II levels and altered vascular reactivity are consistent with a renin-angiotensin-mediated hypertension. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:135 / 141
页数:7
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