New era for personalized medicine: the diagnosis and management of age-related macular degeneration

被引：23

作者：

Baird, Paul N. ^{[1
]}

Hageman, Gregory S. ^{[2
]}

Guymer, Robyn H. ^{[1
]}

机构：

[1] Univ Melbourne, Royal Victorian Eye & Ear Hosp, Ctr Eye Res Australia, Melbourne, Vic 3002, Australia

[2] Univ Iowa, Dept Ophthalmol & Visual Sci, Coralville, IA USA

来源：

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2009年 / 37卷 / 08期

关键词：

age-related macular degeneration; genetic; risk factor; COMPLEMENT FACTOR-H; JAPANESE POPULATION; GENE POLYMORPHISMS; PIGMENT EPITHELIUM; ASSOCIATION; RISK; VARIANT; CFH; SUSCEPTIBILITY; MACULOPATHY;

D O I：

10.1111/j.1442-9071.2009.02136.x

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

P>It can be argued that age-related macular degeneration is one of the best characterized complex trait diseases. Extensive information related to genetic and environmental risk factors exists, and a number of different biological pathways are strongly implicated in its aetiology. Along with recent improvements in high throughput and relatively inexpensive genetic technologies, we are now in a position to consider developing a presymptomatic, personalized approach towards the assessment, management and treatment of this disease. We explore the applicability and challenges of this approach if it is to become commonplace for guiding treatment decisions for individuals with pre-existing disease or for those at high risk of developing it.

引用

页码：814 / 821

页数：8

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