A systematic review and meta-analysis of the association between long non-coding RNA polymorphisms and cancer risk

被引：68

作者：

Lv, Zhi

Xu, Qian ^{[1
]}

Yuan, Yuan ^{[1
]}

机构：

[1] China Med Univ, Affiliated Hosp 1, Tumor Etiol & Screening Dept, Canc Inst & Gen Surg, Shenyang 110001, Peoples R China

来源：

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2017年 / 771卷

基金：

中国国家自然科学基金;

关键词：

lncRNA; Polymorphisms; Cancer; QUANTITATIVE TRAIT LOCI; HOTAIR RS920778 POLYMORPHISM; BREAST-CANCER; GENETIC-VARIANTS; GASTRIC-CANCER; LNCRNA HOTAIR; ZNRD1-AS1; INFLUENCE; TURKISH POPULATION; COLORECTAL-CANCER; TUMOR-SUPPRESSOR;

D O I：

10.1016/j.mrrev.2016.10.002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

It has been suggested that long non-coding RNA (IncRNA) gene polymorphisms are associated with cancer risk. In this article, we conducted a systematic review related to studies on the association between IncRNA single-nucleotide polymorphisms (SNPs) and the overall risk of cancer. A total 17 SNPs in four common IncRNA genes were included in the meta-analysis. In the IncRNA H19, the rs2735971 A/G, rs2839698C/T, and rs3024270 G/C polymorphisms, but not rs217727C/T, were correlated with overall cancer risk. The results also suggested that other SNPs were correlated with overall cancer risk, namely, two in HOTAIR (HOX transcript antisense RNA: rs920778C/T and rs7958904 G/C) and two in PRNCRI (rs1016343C/T and rs16901946 A/G). No association was found between the three ZNRD1-AS1 (ZNRD1 antisense RNA 1) SNPs and the risk of cancer. In summary, our findings suggest that,quite a few studied lncRNA SNPs are associated with overall cancer risk; therefore, they are potential predictive biomarkers for the risk of cancer. Moreover, other IncRNA SNPs investigated were also relevant to cancer but studies on them are limited, and they were also briefly reviewed as candidate cancer markers. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：1 / 14

页数：14

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