Cardiovascular Aging and Longevity JACC State-of-the-Art Review

被引：52
作者：
Pietri, Panagiota [1 ,2 ]
Stefanadis, Christodoulos [1 ,2 ]
机构：
[1] Univ Athens, Athens Med Sch, Tepeleniou 9, Athens 15452, Attica, Greece
[2] Res Inst Longev & Aging Related Dis, Athens, Greece
来源：
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2021年 / 77卷 / 02期
关键词：
aging; cardiovascular disease; longevity; NF-KAPPA-B; CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; LIFE-SPAN; OXIDATIVE STRESS; ARTERIAL STIFFNESS; ENDOTHELIAL FUNCTION; PHYSICAL-ACTIVITY; TELOMERE LENGTH; PREMATURE SENESCENCE;
D O I：
10.1016/j.jacc.2020.11.023
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiovascular aging and longevity are interrelated through many pathophysiological mechanisms. Many factors that promote atherosclerotic cardiovascular disease are also implicated in the aging process and vice versa. Indeed, cardiometabolic disorders such as hyperglycemia, insulin resistance, dystipidemia, and arterial hypertension share common pathophysiological mechanisms with aging and longevity. Moreover, genetic modulators of longevity have a significant impact on cardiovascular aging. The current knowledge of genetic, molecular, and biochemical pathways of aging may serve as a substrate to introduce interventions that might delay cardiovascular aging, thus approaching the goat of longevity. In the present review, the authors describe pathophysiological links between cardiovascular aging and longevity and translate these mechanisms into clinical data by reporting genetic, dietary, and environmental characteristics from long-living populations. (C) 2021 by the American College of Cardiology Foundation.
引用
收藏
页码：189 / 204
页数：16
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