Label-free measurements on the solution of monomeric and dimeric insulin using a periodical terahertz split ring resonator

被引：2
|
作者：
Wang, Pengfei [1 ]
Liu, Liyuan [2 ]
Wang, Xiangchao [3 ]
Zhang, Jianbing [4 ,5 ]
Qi, Wei [3 ]
Zhao, Hongwei [4 ,5 ]
Tian, Zhen [2 ]
He, Mingxia [1 ]
机构：
[1] Tianjin Univ, State Key Lab Precis Measuring Technol & Instrume, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Key Lab Optoelect Informat & Tech Sci, Minist Educ China, Tianjin 300072, Peoples R China
[3] Tianjin Univ, State Key Lab Chem Engn, Tianjin 300072, Peoples R China
[4] Chinese Acad Sci, Div Interfacial Water, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
[5] Chinese Acad Sci, Key Lab Interfacial Phys & Technol, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
来源：
CHEMICAL PHYSICS | 2019年 / 525卷
基金：
中国国家自然科学基金;
关键词：
Terahertz time-domain spectroscopy; Split ring resonator; Insulin aggregates; Dielectric response; PULSED SPECTROSCOPY; METAMATERIAL; DISSOCIATION; AGGREGATION; FILTER;
D O I：
10.1016/j.chemphys.2019.05.017
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A silicon-based sensor, consisting of periodical split ring resonators was demonstrated to monitor monomeric and dimeric insulin solutions in terahertz time-domain spectroscopy (THz-TDS). As concentration increases, the resonant frequencies of sensor show red shifts with a rapid trend in dilute solutions and a slow trend in concentrated solutions, consistent with CST simulations. For monomeric insulin, the turning concentration is 11.6 mg/ml and the total frequency shift is larger than that of dimeric insulin which shows a turning concentration at 17.4 mg/ml. The deviation in frequency shift and turning concentration can be attributed to the structural changes of insulin during dimerization process.
引用
收藏
页数：7
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