Label-free measurements on the solution of monomeric and dimeric insulin using a periodical terahertz split ring resonator

被引：2

作者：

Wang, Pengfei ^{[1
]}

Liu, Liyuan ^{[2
]}

Wang, Xiangchao ^{[3
]}

Zhang, Jianbing ^{[4
,5
]}

Qi, Wei ^{[3
]}

Zhao, Hongwei ^{[4
,5
]}

Tian, Zhen ^{[2
]}

He, Mingxia ^{[1
]}

机构：

[1] Tianjin Univ, State Key Lab Precis Measuring Technol & Instrume, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Key Lab Optoelect Informat & Tech Sci, Minist Educ China, Tianjin 300072, Peoples R China

[3] Tianjin Univ, State Key Lab Chem Engn, Tianjin 300072, Peoples R China

[4] Chinese Acad Sci, Div Interfacial Water, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China

[5] Chinese Acad Sci, Key Lab Interfacial Phys & Technol, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China

来源：

CHEMICAL PHYSICS | 2019年 / 525卷

基金：

中国国家自然科学基金;

关键词：

Terahertz time-domain spectroscopy; Split ring resonator; Insulin aggregates; Dielectric response; PULSED SPECTROSCOPY; METAMATERIAL; DISSOCIATION; AGGREGATION; FILTER;

D O I：

10.1016/j.chemphys.2019.05.017

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A silicon-based sensor, consisting of periodical split ring resonators was demonstrated to monitor monomeric and dimeric insulin solutions in terahertz time-domain spectroscopy (THz-TDS). As concentration increases, the resonant frequencies of sensor show red shifts with a rapid trend in dilute solutions and a slow trend in concentrated solutions, consistent with CST simulations. For monomeric insulin, the turning concentration is 11.6 mg/ml and the total frequency shift is larger than that of dimeric insulin which shows a turning concentration at 17.4 mg/ml. The deviation in frequency shift and turning concentration can be attributed to the structural changes of insulin during dimerization process.

引用

页数：7

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