Enantioselective recognition of amino acids by chiral peptido-calix[4]arenes and thiacalix[4]arenes

被引：18

作者：

Bois, Joackim ^{[1
,2
]}

Bonnamour, Isabelle ^{[1
,2
]}

Duchamp, Christian ^{[1
,2
]}

Parrot-Lopez, Helene ^{[1
,2
]}

Darbost, Ulrich ^{[1
,2
]}

Felix, Caroline ^{[1
,2
]}

机构：

[1] Univ Lyon 1, CNRS, UMR 5246, Inst Chim & Biochim Mol & Supramol,CSAp, F-69622 Villeurbanne, France

[2] Univ Lyon, Lyon, France

来源：

NEW JOURNAL OF CHEMISTRY | 2009年 / 33卷 / 10期

关键词：

ELECTROSPRAY MASS-SPECTROMETRY; ENANTIOMERIC RECOGNITION; OPTICALLY PURE; DERIVATIVES; BEARING; RECEPTORS; PHENYLALANINE; COMPLEXATION; TRYPTOPHAN; PHASE;

D O I：

10.1039/b907190c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to prepare new molecular hosts able to discriminate enantiomers of amino-acid derivatives, we have synthesized chiral thiacalix[4]arenes. Extensive studies using NMR and mass spectrometry techniques allow us to determine the major supramolecular interactions involved in the recognition process. Moreover, a titration study enables us to determine the binding constant between these new hosts and a series of amino-acid derivatives. Finally, we have also demonstrated that these calixarenes are able to discriminate enantiomers of amino-acid guests.

引用

页码：2128 / 2135

页数：8

共 45 条

[11] Partially O-Alkylated thiacalix[4]arenes:: Synthesis, molecular and crystal structures, conformational behavior [J].