11C-Methionine PET of Acute Myocardial Infarction

被引：39

作者：

Morooka, Miyako ^{[1
]}

Kubota, Kazuo ^{[1
]}

Kadowaki, Hiromu ^{[2
]}

Ito, Kimiteru ^{[1
]}

Okazaki, Osamu ^{[2
]}

Kashida, Mitsuo ^{[2
]}

Mitsumoto, Takuya ^{[1
]}

Iwata, Ren ^{[3
]}

Ohtomo, Kuni ^{[4
]}

Hiroe, Michiaki ^{[2
]}

机构：

[1] Int Med Ctr Japan, Dept Radiol, Div Nucl Med, Shinjuku Ku, Tokyo 1628655, Japan

[2] Int Med Ctr Japan, Dept Cardiol, Tokyo 1628655, Japan

[3] Tohoku Univ, Cyclotron Radioisotope Ctr, Dept Radiopharmaceut Chem, Sendai, Miyagi 980, Japan

[4] Univ Tokyo, Dept Radiol, Tokyo, Japan

来源：

JOURNAL OF NUCLEAR MEDICINE | 2009年 / 50卷 / 08期

关键词：

C-11-methionine; myocardial infarction; PET; F-18-FDG; remodeling; POSITRON-EMISSION-TOMOGRAPHY; METHIONINE UPTAKE; CANCER-PATIENTS; ANGIOGENESIS; INTEGRIN; TISSUE; BRAIN;

D O I：

10.2967/jnumed.108.061341

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Tissue uptake of L-[methyl-C-11]-methionine (C-11-methionine) has been used to monitor amino acid metabolism and protein synthesis. We examined whether C-11-methionine was retained in areas of myocardial infarction after successful reperfusion. Methods: Nine patients with infarction in the left anterior descendent region underwent percutaneous transluminal coronary artery intervention within 24 h and Tl-201 SPECT, F-18-FDG PET, and C-11-methionine PET within 2 wk of infarction onset. The standardized uptake values of the infarcted area and of the normal area were measured. Results: The C-11-methionine images showed increased uptake in the infarcted area, whereas the Tl-201 SPECT and F-18-FDG PET images showed decreased uptake. The highest accumulation of C-11-methionine in the infarcted area was observed during the early phase of AMI. Conclusion: C-11-methionine uptake is elevated in infarcted areas and may reflect the early acute phase of damage healing, that is, the initial process of remodeling.

引用

页码：1283 / 1287

页数：5

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