Age distribution of serological profiles of Epstein-Barr virus infection:: review of results from a diagnostic laboratory

INTRODUCTION. The objective of this study was to examine the distribution of serological profiles of Epstein-Barr virus (EBV) infection according to age. METHODS. We retrospectively review EBV specific antibody determinations performed at our hospital between 2003 and 2004. RESULTS. The distribution of acute EBV infection by age showed a bimodal pattern, with peaks at the age of 2-4 years and 14-18 years. Among the 21-30 year-old age group, there was a higher percentage of seronegative men than women. Seroprevalence in patients aged 31 years or more was 99%. CONCLUSIONS. Most primary EBV infections occur in early childhood or adolescence. The increase in seroprevalence takes place at an earlier age in females than in males. EBV seroprevalence in adult patients is very high.