TNF-α gene polymorphisms in Iranian Azeri Turkish patients with Behcet's Disease

被引：36

作者：

Bonyadi, Mortaza ^{[1
,2
]}

Jahanafrooz, Zohreh ^{[1
,2
]}

Esmaeili, Mohsen ^{[2
]}

Kolahi, Susan ^{[3
]}

Khabazi, Alireza ^{[3
]}

Ebrahimi, Ali Asghar ^{[3
]}

Hajialilo, Mehrzad ^{[3
]}

Dastgiri, Saeed ^{[4
]}

机构：

[1] Univ Tabriz, Fac Nat Sci, Ctr Excellence Biodivers, Tabriz, Iran

[2] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran

[3] Med Univ Tabriz, Fac Med, Imam Reza Hosp, Rheumatol Ward, Tabriz, Iran

[4] Tabriz Univ Med Sci, Sch Med, Natl Publ Hlth Management Ctr, Dept Community & Family Med, Tabriz, Iran

来源：

RHEUMATOLOGY INTERNATIONAL | 2009年 / 30卷 / 02期

关键词：

Behcet's disease; TNF-alpha; Polymorphism; Iranian Azeri Turks; Genetic susceptibility; TUMOR-NECROSIS-FACTOR; ASSOCIATION; PROMOTER; REGION; FEVER;

D O I：

10.1007/s00296-009-1134-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetic factors that predispose individuals to Behcet's disease (BD) are considered to play an important role in the development of the disease. The serum level of tumor necrosis factor (TNF) is elevated in patients with BD, and a dramatic response to anti-TNF-alpha antibody treatment further supports the role of TNF in BD. We investigated the distribution of TNF-alpha promoter -1031T/C and -308G/A polymorphisms in 53 BD patients of Iranian Azeri Turks and 79 matched healthy controls, via the PCR-RFLP technique. The frequency of the TNF-alpha -1031C allele was significantly higher in Behcet's patients than in healthy controls (p < 0.0001, OR = 3.08; 95% CI = 1.73-5.47), whereas the frequency of the TNF-alpha -308A allele was similar in the two compared groups. The frequency of CG haplotype was significantly higher (p < 0.0001, OR = 3.42; 95% CI = 1.89-6.18), and that of the TA haplotype was significantly lower in BD patients than in healthy controls. These results suggest that TNF-alpha is a susceptibility gene for BD in patients from Iranian Azeri Turk ethnic group.

引用

页码：285 / 289

页数：5

共 31 条

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