The Role of the O-GlcNAc Modification in Regulating Eukaryotic Gene Expression

被引：23

作者：

Brimble, Sandii ^{[1
]}

Wollaston-Hayden, Edith E. ^{[1
]}

Teo, Chin Fen ^{[1
]}

Morris, Andrew C. ^{[1
]}

Wells, Lance ^{[1
]}

机构：

[1] Univ Georgia, Dept Chem, Dept Biochem & Mol Biol, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA

来源：

CURRENT SIGNAL TRANSDUCTION THERAPY | 2010年 / 5卷 / 01期

关键词：

O-GlcNAc; transcriptional regulation; post-translational modification; review; LINKED N-ACETYLGLUCOSAMINE; ESTROGEN-RECEPTOR-BETA; RNA-POLYMERASE-II; CREB COACTIVATOR TORC2; FRAGILE-X-SYNDROME; KAPPA-B PATHWAY; TRANSCRIPTION FACTORS; INSULIN-RESISTANCE; MODIFIED PROTEINS; POSTTRANSLATIONAL MODIFICATIONS;

D O I：

10.2174/157436210790226465

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of proteins has been shown to be involved in many different cellular processes, such as cell cycle control, nutrient sensing, signal transduction, stress response and transcriptional regulation. Cells have developed complex regulatory systems in order to regulate gene expression appropriately in response to environmental and intracellular cues. Control of eukaryotic gene transcription often involves post-translational modification of a multitude of proteins including transcription factors, basal transcription machinery, and chromatin remodeling complexes to modulate their functions in a variety of manners. In this review we describe the emerging functional roles for and techniques to detect and modulate the O-GlcNAc modification and illustrate that the O-GlcNAc modification is intricately involved in at least seven different general mechanisms for the control of gene transcription.

引用

页码：12 / 24

页数：13

共 145 条

[31] Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1 [J].