Results of darbepoetin alfa treatment of anaemia in chemotherapy-receiving breast cancer patients: a single-centre retrospective observational study

被引：1

作者：

Jagiello-Gruszfeld, Agnieszka ^{[1
]}

Niwinska, Anna ^{[1
]}

Michalski, Wojciech ^{[2
]}

Pogoda, Katarzyna ^{[1
]}

Dubianski, Roman ^{[1
]}

Kunkiel, Michal ^{[1
]}

Lemanska, Izabela ^{[1
]}

Sienkiewicz, Renata ^{[1
]}

Gorniak, Anna ^{[1
]}

Kosakowska, Ewa ^{[3
]}

Nowecki, Zbigniew ^{[1
]}

机构：

[1] Maria Sklodowska Curie Natl Inst Oncol, Clin Breast Canc & Reconstruct Surg, Ul Roentgen 5, PL-02781 Warsaw, Poland

[2] Maria Sklodowska Curie Natl Inst Oncol, Dept Oncol Math, Warsaw, Poland

[3] Med Postgrad Educ Ctr, Clin Oncol & Breast Dis, Warsaw, Poland

来源：

ONCOLOGY IN CLINICAL PRACTICE | 2021年 / 17卷 / 06期

关键词：

chemotherapy-induced anaemia; breast cancer; darbepoetin alfa; erythropoietin-stimulating agents; ERYTHROPOIESIS-STIMULATING AGENTS; EPOETIN ALPHA; CLINICAL-OUTCOMES; INTRAVENOUS IRON; PHASE-III; MANAGEMENT; TRANSFUSION; HEMOGLOBIN; TRIAL; MALIGNANCIES;

D O I：

10.5603/OCP.2020.0048

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A retrospective observational study of the outcomes of darbepoetin alfa treatment for chemotherapy-induced anaemia in breast cancer patients was conducted. A group of 152 patients treated during 13 months in one oncology centre was assessed. Ninety-eight patients (64.5%) received perioperative chemotherapy, and 54 pa-tients (35.5%) received palliative chemotherapy. The results of treatment with darbepoetin alfa were analysed by age (< 65 vs. >= 65 years), the aim of chemotherapy (perioperative vs. palliative), and body mass index (< 25 vs. 25-29 vs. 30 and more). The effectiveness of the therapy was estimated at 80.9% (95% CI: 74.7-87.2%). Significantly higher effectiveness of ESA was found in patients treated perioperatively compared to patients treated for metastatic breast cancer (85.7% vs. 72.2%, p = 0.043). There were no differences in the effectiveness of ESA depending on age and BMI. No serious ESA-related adverse events were observed.

引用

页码：237 / 243

页数：7

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