Morpholino-based peptide oligomers: Synthesis and DNA binding properties

被引：4

作者：

Contini, Alessandro ^{[1
]}

Erba, Emanuela ^{[1
]}

Bondavalli, Valeria ^{[1
]}

Barbiroli, Alberto ^{[2
]}

Gelmi, Maria Luisa ^{[1
]}

Romanelli, Alessandra ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Sci Farmaceut, Milan, Italy

[2] Univ Milan, DeFENS Dipartimento Sci Alimenti Nutr & Ambiente, Milan, Italy

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2021年 / 549卷

关键词：

Morpholino; Peptide; Circular dichroism; Molecular modelling; DNA;

D O I：

10.1016/j.bbrc.2021.02.087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemical structure of oligonucleotide analogues dictates the conformation of oligonucleotide analogue oligomers, their ability to hybridize complementary DNA and RNA, their stability to degradation and their pharmacokinetic properties. In a study aimed at investigating new analogues featuring a neutral backbone, we explored the ability of oligomers containing a morpholino-peptide backbone to bind oligonucleotides. Circular Dichroism studies revealed the ability of our oligomers to interact with DNA, molecular modelling studies revealed the interaction responsible for complex stabilization. ? 2021 Elsevier Inc. All rights reserved.

引用

页码：8 / 13

页数：6

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