Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

被引：806

作者：

Kaupmann, K ^{[1
]}

Huggel, K ^{[1
]}

Heid, J ^{[1
]}

Flor, PJ ^{[1
]}

Bischoff, S ^{[1
]}

Mickel, SJ ^{[1
]}

McMaster, G ^{[1
]}

Angst, C ^{[1
]}

Bittiger, H ^{[1
]}

Froestl, W ^{[1
]}

Bettler, B ^{[1
]}

机构：

[1] NOVARTIS PHARMA INC,RES DEPT,THERAPEUT AREA NERVOUS SYST,CH-4002 BASEL,SWITZERLAND

来源：

NATURE | 1997年 / 386卷 / 6622期

关键词：

D O I：

10.1038/386239a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

GABA (gamma-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABA(A)/ GABA(C)) and metabotropic (GABA(B)) receptor systems. Here we report the cloning of GABA(B) receptors. Photoaffinity labelling experiments suggest that the cloned receptors correspond to two highly conserved GABA(B) receptor forms present in the vertebrate nervous system. The cloned receptors negatively couple to adenylyl cyclase and show sequence similarity to the metabotropic receptors for the excitatory neurotransmitter L-glutamate.

引用

页码：239 / 246

页数：8

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