Experimental cryosurgery investigations in vivo

被引：209

作者：

Gage, A. A. ^{[2
]}

Baust, J. M. ^{[1
,3
,4
]}

Baust, J. G. ^{[1
,3
]}

机构：

[1] SUNY Binghamton, Inst Biomed Technol, Binghamton, NY 13902 USA

[2] SUNY Buffalo, Dept Surg, Buffalo, NY 14260 USA

[3] SUNY Binghamton, Dept Biol Sci, Binghamton, NY 13902 USA

[4] Cell Preservat Serv Inc, Owego, NY USA

来源：

CRYOBIOLOGY | 2009年 / 59卷 / 03期

关键词：

Cryosurgery; Cryoablation; Cryotherapy; ACUTE LUNG INJURY; EXPERIMENTAL HEPATIC CRYOSURGERY; PERIPHERAL RETINAL ABLATION; POSTERIOR PAPILLARY-MUSCLE; MINIMALLY INVASIVE SURGERY; RADIO-FREQUENCY ABLATION; PULMONARY VEIN ISOLATION; NECROSIS-FACTOR-ALPHA; MITRAL-VALVE FUNCTION; TERM-FOLLOW-UP;

D O I：

10.1016/j.cryobiol.2009.10.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cryosurgery is the use of freezing temperatures to elicit an ablative response in a targeted tissue. This review provides a global overview of experimentation in vivo which has been the basis of advancement of this widely applied therapeutic option. The cellular and tissue-related events that underlie the mechanisms of destruction, including direct cell injury (cryolysis), vascular stasis, apoptosis and necrosis, are described and are related to the optimal methods of technique of freezing to achieve efficacious therapy. In vivo experiments with major organs, including wound healing, the putative immunological response following thawing, and the use of cryoadjunctive strategies to enhance cancer cell sensitivity to freezing, are described. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：229 / 243

页数：15

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