Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod

被引：34
作者：
Abbo, Lillian
Vincek, Vladimir
Dickinson, Gordon
Shrestha, Niraj
Doblecki, Susanne
Haslett, Patrick A. J.
机构：
[1] Univ Miami, Miller Sch Med, Miami, FL 33152 USA
[2] Vet Adm Med Ctr, Miami, FL 33125 USA
来源：
CLINICAL INFECTIOUS DISEASES | 2007年 / 44卷 / 03期
关键词：
D O I：
10.1086/510426
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We report a case of acquired immunodeficiency syndrome ( AIDS) - associated, acyclovir- refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon-alpha response following in vitro stimulation with imidazoquinolinebut not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferona may be overcome by stimulating intact alternative pathways.
引用
收藏
页码：E25 / E27
页数：3
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