Blood-based PD-L1 analysis in tumor-derived extracellular vesicles: Applications for optimal use of anti-PD-1/PD-L1 axis inhibitors

被引：17

作者：

Del Re, Marzia ^{[1
]}

van Schaik, Ron Hn ^{[2
]}

Fogli, Stefano ^{[1
]}

Mathijssen, Ron Hj ^{[3
]}

Cucchiara, Federico ^{[1
]}

Capuano, Annalisa ^{[4
]}

Scavone, Cristina ^{[4
]}

Jenster, Guido W. ^{[5
]}

Danesi, Romano ^{[1
]}

机构：

[1] Univ Pisa, Dept Clin & Expt Med, Unit Clin Pharmacol & Pharmacogenet, 55 Via Roma, I-56126 Pisa, Italy

[2] Erasmus MC, Dept Clin Chem, Rotterdam, Netherlands

[3] Erasmus MC Canc Inst, Dept Med Oncol, Rotterdam, Netherlands

[4] Univ Campania Luigi Vanvitelli, Dept Expt Med, Naples, Italy

[5] Erasmus MC Canc Inst, Dept Urol, Rotterdam, Netherlands

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2021年 / 1875卷 / 01期

关键词：

Extracellular vesicles; Exosomes; PD-1/PD-L1; Liquid biopsy; Cancer; Immune-checkpoint inhibitors; EXOSOMES; CANCER; EXPRESSION; PLASMA; PROSTASOMES; SUPPRESSION; ACTIVATION; MECHANISMS; MATURATION; BIOMARKER;

D O I：

10.1016/j.bbcan.2020.188463

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monoclonal antibodies that inhibit the programmed cell death protein 1 axis (anti-PD-1/PD-L1) are part of a new pharmacological strategy aimed at reinforcing the immune response to cancer. Despite the success in several cancer types, a significant percentage of patients do not benefit from treatment with these drugs due to intrinsic or acquired resistance or the occurrence of immune-related adverse reactions. Assessment of PD-L1 expression in tumor tissues is currently used to predict drug response in the clinics; however, there is a growing interest in identifying blood-based biomarkers that, owing to the minimally-invasive nature, can allow a dynamic monitoring of drug response in daily clinical practice. In the current review article, we discuss whether the assessment of PD-L1 mRNA and protein levels in circulating extracellular vesicles may have the potential to predict the likelihood of tumor response to anti-PD-1/PD-L1 antibodies.

引用

页数：9

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