Topiramate and asymptomatic ocular angle narrowing: a prospective pilot study

被引：9
作者：
Leung, D. Y. L. [1 ]
Leung, H. [2 ]
Baig, N. [1 ]
Kwan, P. [2 ]
Kwong, Y. Y. Y. [1 ]
Wong, K. S. [2 ]
Lam, D. S. C. [1 ]
机构：
[1] Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong Eye Hosp, Kowloon, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
来源：
EYE | 2009年 / 23卷 / 11期
关键词：
Topiramate; acute angle-closure glaucoma; ultrasound biomicroscopy; CLOSURE GLAUCOMA; ULTRASOUND BIOMICROSCOPY; PHACOEMULSIFICATION; MANAGEMENT; IRIDOTOMY; EYES;
D O I：
10.1038/eye.2009.93
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose To investigate whether subclinical ciliochoroidal effusion and resulting asymptomatic angle narrowing occurs in patients taking topiramate, by ultrasound biomicroscopy (UBM). Methods Chinese patients aged 18-75 years for whom topiramate was indicated were recruited. Examinations including UBM were performed before and 4 weeks after commencement of topiramate. Results In this pilot of 20 eyes of 20 patients, there were no statistically significant changes in the angle parameters noted on gonioscopy or UBM, including anterior chamber depth, angle-opening distance at 500 mu m, trabecular ciliary process distance, trabecular-iris angle, and scleral thickness. Conclusion Short-term use of topiramate does not induce asymptomatic angle narrowing. Eye (2009) 23, 2079-2081; doi:10.1038/eye.2009.93; published online 1 May 2009
引用
收藏
页码：2079 / 2081
页数：3
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