Infant gut immunity: a preliminary study of IgA associations with breastfeeding

被引：38

作者：

Bridgman, S. L. ^{[1
]}

Konya, T. ^{[2
]}

Azad, M. B. ^{[3
]}

Sears, M. R. ^{[4
]}

Becker, A. B. ^{[3
]}

Turvey, S. E. ^{[5
,6
]}

Mandhane, P. J. ^{[1
]}

Subbarao, P. ^{[7
]}

Scott, J. A. ^{[2
]}

Field, C. J. ^{[9
]}

Kozyrskyj, A. L. ^{[1
]}

机构：

[1] Univ Alberta, Dept Pediat, Edmonton, AB T6G IC9, Canada

[2] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[3] Univ Manitoba, Childrens Hosp Res Inst Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB, Canada

[4] McMaster Univ, de Groote Sch Med, Dept Med, Hamilton, ON, Canada

[5] Univ British Columbia, Dept Pediat, Child & Family Res Inst, Vancouver, BC V6T 1W5, Canada

[6] Univ British Columbia, BC Childrens Hosp, Vancouver, BC V5Z 1M9, Canada

[7] Univ Toronto, Hosp Sick Children, Dept Pediat, Toronto, ON M5G 1X8, Canada

[8] Canadian Hlth Infant Longitudinal Dev Study, Edmonton, AB, Canada

[9] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G IC9, Canada

来源：

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE | 2016年 / 7卷 / 01期

关键词：

breastfeeding; immunoglobulin A; parity; pets; SECRETORY IMMUNOGLOBULIN-A; FORMULA-FED INFANTS; HUMAN-MILK; INTESTINAL MICROBIOTA; ATOPIC-DERMATITIS; FECES;

D O I：

10.1017/S2040174415007862

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Secretory immunoglobulin A (IgA) plays a critical role in gut mucosal immune defense. Initially provided by breastmilk, IgA production by the infant gut is gradually stimulated by developing gut microbiota. This study reports associations between infant fecal IgA concentrations 4 months after birth, breastfeeding status and other pre/postnatal exposures in 47 infants in the Canadian Healthy Infant Longitudinal Development cohort. Breastfed infants and first-born infants had higher median fecal IgA concentrations (23.11 v. 9.34 mu g/g protein, P< 0.01 and 22.19 v. 8.23 mu g/g protein, P = 0.04). IgA levels increased successively with exclusivity of breastfeeding (beta-coefficient, 0.37, P< 0.05). This statistical association was independent of maternal parity and household pets. In the absence of breastfeeding, female sex and pet exposure elevated fecal IgA to levels found in breastfed infants. In addition to breastfeeding, infant fecal IgA associations with pre/postnatal exposures may affect gut immunity and risk of allergic disease.

引用

页码：68 / 72

页数：5

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