Utilizing melatonin to combat bacterial infections and septic injury

被引：56

作者：

Hu, Wei ^{[1
,2
]}

Deng, Chao ^{[3
,4
]}

Ma, Zhiqiang ^{[5
]}

Wang, Dongjin ^{[1
]}

Fan, Chongxi ^{[5
]}

Li, Tian ^{[2
]}

Di, Shouyin ^{[5
]}

Gong, Bing ^{[1
]}

Reiter, Russel J. ^{[6
]}

Yang, Yang ^{[1
,2
]}

机构：

[1] Nanjing Univ, Sch Med, Dept Thorac & Cardiovasc Surg, Nanjing Drum Tower Hosp,Affiliated Hosp, 321 Zhongshan Rd, Nanjing, Jiangsu, Peoples R China

[2] Fourth Mil Med Univ, Dept Biomed Engn, Xian, Peoples R China

[3] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiovasc Surg, Xian, Peoples R China

[4] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, Xian, Peoples R China

[5] Fourth Mil Med Univ, Dept Aerosp Med, Xian, Peoples R China

[6] UT Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2017年 / 174卷 / 09期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

NLRP3 INFLAMMASOME ACTIVATION; NF-KAPPA-B; ORGAN DYSFUNCTION SYNDROME; ESCHERICHIA-COLI O157-H7; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; EXOGENOUS MELATONIN; CONCISE GUIDE; RAT MODEL;

D O I：

10.1111/bph.13751

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Melatonin, also known as N-acetyl-5-methoxytryptamine, is a ubiquitously acting molecule that is produced by the pineal gland and other organs of animals, including humans. As melatonin and its metabolites are potent antioxidants and free radical scavengers, they are protective against a variety of disorders. Moreover, multiple molecular targets of melatonin have been identified, and its actions are both receptor-mediated and receptor-independent. Recent studies have shown that melatonin may be useful in fighting against sepsis and septic injury due to its antioxidative and anti-inflammatory actions; the results generally indicate a promising therapeutic application for melatonin in the treatment of sepsis. To provide a comprehensive understanding regarding the protective effects of melatonin against septic injury, in the present review we have evaluated the published literature in which melatonin has been used to treat experimental and clinical sepsis. Firstly, we present the evidence from studies that have used melatonin to resist bacterial pathogens. Secondly, we illustrate the protective effect of melatonin against septic injury and discuss the possible mechanisms. Finally, the potential directions for future melatonin research against sepsis are summarized.

引用

页码：754 / 768

页数：15

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