Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes

被引：65
|
作者：
Membrino, Alexandro [2 ]
Paramasivam, Manikandan [2 ]
Cogoi, Susanna [2 ]
Alzeer, Jawad [1 ]
Luedtke, Nathan W. [1 ]
Xodo, Luigi E. [2 ]
机构：
[1] Univ Zurich, Inst Organ Chem, CH-8057 Zurich, Switzerland
[2] Univ Udine, Dept Biomed Sci & Technol, I-33100 Udine, Italy
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 04期
基金：
瑞士国家科学基金会;
关键词：
HUMAN KRAS PROMOTER; SMALL-MOLECULE; DNA-STRUCTURE; REGION; GENE; PROTOONCOGENE; 5'-UTR;
D O I：
10.1039/b918964e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Guanidino-modified phthalocyanines are evaluated in vitro (polymerase-stop assays and FRET) and in cultured cells as G4-DNA ligands and modulators of gene transcription.
引用
收藏
页码：625 / 627
页数：3
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