FGF23 and inflammation-a vicious coalition in CKD

被引：33

作者：

Czaya, Brian ^{[1
]}

Faul, Christian ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Med, Div Nephrol, Birmingham, AL 35294 USA

来源：

KIDNEY INTERNATIONAL | 2019年 / 96卷 / 04期

关键词：

D O I：

10.1016/j.kint.2019.05.018

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

High serum concentrations of the phosphaturic hormone, fibroblast growth factor 23 (FGF23), contribute to various tissue injuries. In chronic kidney disease, the sources of FGF23 and the stimuli that control FGF23 production differ from those in the physiologic scenario. Mediators of inflammation are intensively studied as potential factors that contribute to FGF23 elevations and thereby might function as drug targets to lower FGF23 levels. The present study focuses on tumor necrosis factor.

引用

页码：813 / 815

页数：3

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