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- [6] Different functions of the two isoforms of osteopontin (iOPN and sOPN) in the proliferation and differentiation of osteoblast and osteoclast: iOPN inhibits osteoclasts' proliferation while sOPN stimulates osteoblasts' differentiation and osteoclasts' resorption INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 10 (01): : 224 - 241