Practical Method for Preparation of (S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution

被引：22

作者：

Mei, Haibo ^{[1
]}

Han, Jianlin ^{[1
]}

Takeda, Ryosuke ^{[2
,3
]}

Sakamoto, Tsubasa ^{[2
]}

Miwa, Toshio ^{[2
]}

Minamitsuji, Yutaka ^{[2
]}

Moriwaki, Hiroki ^{[2
]}

Abe, Hidenori ^{[2
]}

Soloshonok, Vadim A. ^{[3
,4
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China

[2] Hamari Chem Ltd, Higashi Yodogawa Ku, 1-4-29 Kunijima, Osaka 5330024, Japan

[3] Univ Basque Country, UPV EHU, Dept Organ Chem 1, Fac Chem, Paseo Manuel Lardizabal 3, San Sebastian 20018, Spain

[4] IKERBASQUE Basque Fdn Sci, Maria Diaz de Haro 3,Plaza Bizkaia, Bilbao 48013, Spain

来源：

ACS OMEGA | 2019年 / 4卷 / 07期

基金：

中国国家自然科学基金;

关键词：

ALPHA-AMINO-ACIDS; F-19 NMR LABEL; NUCLEOPHILIC GLYCINE EQUIVALENTS; SCALE ASYMMETRIC-SYNTHESIS; FLUORINE-CONTAINING AMINES; NI(II) COMPLEXES; SELF-DISPROPORTIONATION; STEREODIVERGENT SYNTHESIS; ADDITION-REACTIONS; R INTERCONVERSION;

D O I：

10.1021/acsomega.9b01537

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This work reports an operationally convenient similar to 20 g scale synthesis of (S)-2-amino-5,5,5-trifluoropentanoic acid and its Fmoc-derivative via dynamic kinetic resolution of the corresponding racemate.

引用

页码：11844 / 11851

页数：8

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