Structure of an HIV-2 gp120 in Complex with CD4

被引：13

作者：

Davenport, Yunji W. ^{[1
,2
]}

West, Anthony P., Jr. ^{[1
]}

Bjorkman, Pamela J. ^{[1
]}

机构：

[1] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

JOURNAL OF VIROLOGY | 2016年 / 90卷 / 04期

关键词：

CRYSTAL-STRUCTURE; ANTIBODY; REFINEMENT; REVEALS; NEUTRALIZATION; EVOLUTION; FEATURES; EPITOPE; PHENIX; MODEL;

D O I：

10.1128/JVI.02678-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-2 is a nonpandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term nonprogression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30 to 40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0-angstrom structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence.

引用

页码：2112 / 2118

页数：7

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