Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria

被引：28

作者：

Whitt, Jedidiah ^{[1
]}

Duke, Cameron ^{[1
]}

Ali, Mohamad Akbar ^{[3
]}

Chambers, Steven A. ^{[1
]}

Khan, Md Mahbub Kabir ^{[1
]}

Gilmore, David ^{[2
]}

Alam, Mohammad A. ^{[1
]}

机构：

[1] Arkansas State Univ, Coll Sci & Math, Dept Chem & Phys, Jonesboro, AR 72467 USA

[2] Arkansas State Univ, Coll Sci & Math, Dept Biol Sci, Jonesboro, AR 72467 USA

[3] King Faisal Univ, Coll Sci, Dept Chem, Al Hasa 31982, Saudi Arabia

来源：

ACS OMEGA | 2019年 / 4卷 / 10期

基金：

美国国家卫生研究院;

关键词：

DERIVATIVES;

D O I：

10.1021/acsomega.9b01967

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 mu g/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay.

引用

页码：14284 / 14293

页数：10

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