Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria

被引：28
|
作者：
Whitt, Jedidiah [1 ]
Duke, Cameron [1 ]
Ali, Mohamad Akbar [3 ]
Chambers, Steven A. [1 ]
Khan, Md Mahbub Kabir [1 ]
Gilmore, David [2 ]
Alam, Mohammad A. [1 ]
机构：
[1] Arkansas State Univ, Coll Sci & Math, Dept Chem & Phys, Jonesboro, AR 72467 USA
[2] Arkansas State Univ, Coll Sci & Math, Dept Biol Sci, Jonesboro, AR 72467 USA
[3] King Faisal Univ, Coll Sci, Dept Chem, Al Hasa 31982, Saudi Arabia
来源：
ACS OMEGA | 2019年 / 4卷 / 10期
基金：
美国国家卫生研究院;
关键词：
DERIVATIVES;
D O I：
10.1021/acsomega.9b01967
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 mu g/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay.
引用
收藏
页码：14284 / 14293
页数：10
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