Convenient method for monitoring Aβ aggregation by quartz-crystal microbalance

被引：17
|
作者：
Okuno, Hiroaki
Mori, Kanae
Jitsukawa, Tomofumi
Inoue, Hiromi
Chiba, Shinya
机构：
[1] Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan
[2] Initium Inc, Chuo Ku, Tokyo 1040028, Japan
来源：
CHEMICAL BIOLOGY & DRUG DESIGN | 2006年 / 68卷 / 05期
关键词：
aggregation; Alzheimer's disease; amyloid protein; quartz-crystal microbalance;
D O I：
10.1111/j.1747-0285.2006.00446.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have found that a quartz-crystal microbalance is a facile and useful tool for detecting the specific aggregation of the amyloid-beta peptides responsible for Alzheimer's disease. This method greatly reduces the time and samples (corresponds to 1 Hz frequency decrease per 30 pg mass increase on a 4.9 mm(2) electrode) that are needed in the aggregation assay, and is also applicable to molecular interactions between smaller amyloid-beta fragment peptides such as the pentapeptide KLVFF.
引用
收藏
页码：273 / 275
页数：3
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