Study on Inclusion Complex Formation of Curcumin with β-Cyclodextrin by Spectrophotometry

被引：0
作者：
Kuang, Chun-tao [1 ]
Li, Xiang-zhou [1 ]
Xue, Hai-peng [1 ]
Su, Qiang [1 ]
Guo, Yuan-liang [1 ]
机构：
[1] Cent S Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Peoples R China
来源：
PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2 | 2009年
关键词：
curcumin; beta-cyclodextrin; inclusion complex; apparent formation constant; spectrophotometry; thermodynamic parameter; PHOTOCHEMICAL STABILITY; LIPID-PEROXIDATION; RAT-LIVER; INHIBITION; DEGRADATION; ANTITUMOR; ANALOGS; LONGA;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The inclusion complex formation of curcumin with beta-CD was studied by spectrophotometry, and the apparent formation constant for curcumin-beta-CD complex was determined. The stiochiometric ratio of curcumin-beta-CD complex was investigated by Job's continuous variation methods. The results showed that a 1: 1 complex between curcumin and P-CD was formed, and the apparent formation constants decreased with the increase of reaction temperature. The thermodynamic parameters, standard free energy (Delta G degrees), enthalpy (Delta H degrees) and entropy (Delta S degrees) for complex formation of curcumin with beta-CD were calculated. The inclusion complex was confirmed by infrared spectrum (IR) and thermogravimetric analysis (TGA).
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页码：254 / 258
页数：5
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