Alkaloids of fascaplysin are promising chemotherapeutic agents for the treatment of glioblastoma: Review

被引：6

作者：

Lyakhova, Irina ^{[1
]}

Piatkova, Mariia ^{[1
]}

Gulaia, Valeriia ^{[2
]}

Romanishin, Aleksandr ^{[2
]}

Shmelev, Mikhail ^{[2
]}

Bryukhovetskiy, Andrey ^{[3
]}

Sharma, Aruna ^{[4
]}

Sharma, Hari Shanker ^{[4
]}

Khotimchenko, Rodion ^{[1
,5
]}

Bryukhovetskiy, Igor ^{[1
,5
]}

机构：

[1] Far Eastern Fed Univ, Sch Biomed, Dept Fundamental Med, Vladivostok, Russia

[2] Far Eastern Fed Univ, Sch Biomed, Dept Med Biol & Biotechnol, Lab Biomed Cell Technol, Vladivostok, Russia

[3] NeuroVita Clin Intervent & Restorat Neurol & Ther, Moscow, Russia

[4] Uppsala Univ, Univ Hosp, Dept Surg Sci Anesthesiol & Intens Care Med, Int Expt Cent Nervous Syst Injury & Repair IECNSI, S-75185 Uppsala, Sweden

[5] Russian Acad Sci, Natl Sci Ctr Marine Biol, Far East Branch, Pharmacol Lab, Vladivostok, Russia

来源：

NOVEL THERAPEUTIC ADVANCES IN GLIOBLASTOMA | 2020年 / 151卷

关键词：

BLOOD-BRAIN-BARRIER; NEWLY-DIAGNOSED GLIOBLASTOMA; CENTRAL-NERVOUS-SYSTEM; ACUTE PROMYELOCYTIC LEUKEMIA; MUTANT P53; ARSENIC TRIOXIDE; PHASE-II; RETINOIC ACID; GROWTH ARREST; GLIOMA-CELLS;

D O I：

10.1016/bs.irn.2020.03.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma is one of the most aggressive human brain tumors. Even following all the modern protocols of complex treatment, the median patient survival typically does not exceed 15 months. This review analyzes the main reasons for glioblastoma resistance to therapy, as well as attempts at categorizing the main approaches to increasing chemotherapy efficiency. Special emphasis is placed on the specific group of compounds, known as marine alkaloids and their synthetic derivatives exerting a general antitumor effect on glioblastoma cells. The unique mechanisms of marine alkaloid influence on the tumor cells prompt considering them as a promising basis for creating new chemotherapeutic agents for glioblastoma treatment.

引用

页码：299 / 324

页数：26

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