Strengths and Limitations of Using the Polypill in Cardiovascular Prevention

被引：44

作者：

Roy, Ambuj ^{[1
]}

Naik, Nitish ^{[1
]}

Reddy, K. Srinath ^{[2
]}

机构：

[1] Publ Hlth Fdn India, New Delhi, India

[2] Publ Hlth Fdn India, Inst Area, Plot 47,Sect 44, Gurugram 122002, India

来源：

CURRENT CARDIOLOGY REPORTS | 2017年 / 19卷 / 05期

关键词：

Polypill; Fixed dose combination; Cardiovascular diseases; Adherence; Secondary prevention; Primary prevention; LOW-INCOME COUNTRIES; ALL-CAUSE MORTALITY; HIGH-RISK; BLOOD-PRESSURE; MIDDLE-INCOME; DISEASE; ADHERENCE; STRATEGY; INDIVIDUALS; CHOLESTEROL;

D O I：

10.1007/s11886-017-0853-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of Review Polypill and its role in cardiovascular disease (CVD) prevention has been extensively discussed and debated since the inception of the concept in 2003. This article reviews the subsequent accumulated research in this area. Recent Findings Several short and intermediate to long-term studies with different brands of polypills have analysed the impact of polypill in phase II and III trials. The strengths of polypill that have emerged include better adherence, equivalent or better risk factor control and quality of life among polypill users as compared to usual care. The lurking limitations include difficulty with dose adjustment to targets, fear of mass medicalisation and low acceptability among physicians. Summary The current literature supports polypill use in reducing blood pressure and cholesterol levels for CVD prevention with improvement in adherence to medication. However, the long-term outcome of polypill on CVD events and mortality are unavailable and are currently being studied in clinical trials.

引用

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