Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

被引：42

作者：

Zhou, Xian ^{[1
]}

Zhu, Xingxing ^{[1
]}

Li, Chaofan ^{[2
]}

Li, Yanfeng ^{[1
]}

Ye, Zhenqing ^{[3
]}

Shapiro, Virginia Smith ^{[4
]}

Copland, John A., III ^{[5
]}

Hitosugi, Taro ^{[6
]}

Bernlohr, David A. ^{[7
]}

Sun, Jie ^{[2
,4
]}

Zeng, Hu ^{[1
,4
]}

机构：

[1] Mayo Clin, Div Rheumatol, Dept Med, Rochester, MN 55905 USA

[2] Mayo Clin, Div Pulm & Crit Care Med, Dept Med, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Biostat & Informat, Rochester, MN 55905 USA

[4] Mayo Clin, Dept Immunol, Rochester, MN 55905 USA

[5] Mayo Clin, Dept Canc Biol, Jacksonville, FL 32224 USA

[6] Mayo Clin, Dept Oncol, Rochester, MN 55905 USA

[7] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA

来源：

CELL REPORTS | 2021年 / 34卷 / 01期

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION; PROTECTS MICE; B-LYMPHOCYTES; INFLUENZA; REQUIREMENT; DISRUPTION; MTORC1; DIFFERENTIATION; LIPOGENESIS; METABOLISM;

D O I：

10.1016/j.celrep.2020.108601

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.

引用

页数：19

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