Is breast cancer a result of epigenetic responses to traffic-related air pollution? A review of the latest evidence

被引:26
作者
Sahay, Debashish [1 ]
Terry, Mary B. [2 ,3 ]
Miller, Rachel [1 ,3 ,4 ,5 ]
机构
[1] Columbia Univ, Coll Phys & Surg, Dept Med, Div Pulm Allergy & Crit Care Med, New York, NY 10032 USA
[2] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA
[3] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA
[4] Columbia Univ, Coll Phys & Surg, Dept Pediat, Div Pediat Allergy Immunol & Rheumatol, New York, NY 10032 USA
[5] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY 10032 USA
关键词
breast cancer risk; DNA methylation; epigenetic regulation; traffic-related air pollution; windows of susceptibility; POLYCYCLIC AROMATIC-HYDROCARBONS; LONG-TERM EXPOSURE; PARTICULATE MATTER; NITROGEN-DIOXIDE; DNA METHYLATION; PROMOTER METHYLATION; RISK; WOMEN; ADDUCTS; LIFE;
D O I
10.2217/epi-2018-0158
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Environmental toxicants can exert adverse health effects via epigenetic regulation. We conducted a review of studies assessing traffic-related air pollution (TRAP) exposure and breast cancer (BC) risk, and the evidence for epigenetic mediation. 14 epidemiological studies demonstrated associations between TRAP exposure and BC risk, in which a total of 26 comparisons were assessed. 11 of these comparisons reported a positive association; whereas 15 comparisons were negative. Five publications linked TRAP exposure to epigenetic alterations in genes that may be related to BC risk. One animal study provided evidence of TRAP-treatment inducing breast tumorigenesis. Associations between TRAP components polycyclic aromatic hydrocarbons (PAH) and nitrogen dioxide (NO2) and BC risk were more consistent. While evidence for epigenetic regulation remains limited, polycyclic aromatic hydrocarbons (PAH) and nitrogen dioxide (NO2) exposures may alter methylation of breast tumorigenic genes (e.g., EPHB2, LONP1). Future epigenomic studies with environmental measures are needed to interrogate the relationship between TRAP and BC risk.
引用
收藏
页码:701 / 714
页数:14
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