Inhibition of lung metastasis in mice by intravascular injection of dendritic cells and natural killer cells

被引：1

作者：

Lv, Hui-fang ^{[1
]}

Cui, Feng ^{[1
]}

Yu, Chang-hua ^{[1
]}

Deng, Li-li ^{[1
]}

Ji, Jing-jing ^{[1
]}

Lu, Dan ^{[1
]}

Yang, Yu ^{[1
]}

Wang, Wen-xiu ^{[1
]}

Xu, Yu-qing ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Oncol, Harbin 150086, Heilongjiang, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2009年 / 31卷 / 11期

关键词：

Cancer; Cytotoxic lymphocyte; Dendritic cell; Immunotherapy; Killer cells; Melanoma cells; IMMUNITY; GENERATION; ACTIVATION; SECRETION; MELANOMA; HMGB1; DCS;

D O I：

10.1007/s10529-009-0072-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To investigate the efficacy of dendritic cells and natural killer cells in the inhibition of lung metastasis, we injected dendritic cells and natural killer cells intravascularly into mice bearing B16F10 tumour melanoma cells. This efficiently inhibited tumor growth and prolonged survival. In addition, surviving mice developed a long-lasting memory response against the original tumor when re-challenged with live tumor cells. Intravenous administration of dendritic cells and natural killer cells may be a potential way to treat lung metastasis in patients.

引用

页码：1709 / 1715

页数：7

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