Inhibition of lung metastasis in mice by intravascular injection of dendritic cells and natural killer cells

被引:1
作者
Lv, Hui-fang [1 ]
Cui, Feng [1 ]
Yu, Chang-hua [1 ]
Deng, Li-li [1 ]
Ji, Jing-jing [1 ]
Lu, Dan [1 ]
Yang, Yu [1 ]
Wang, Wen-xiu [1 ]
Xu, Yu-qing [1 ]
机构
[1] Harbin Med Univ, Affiliated Hosp 2, Dept Oncol, Harbin 150086, Heilongjiang, Peoples R China
关键词
Cancer; Cytotoxic lymphocyte; Dendritic cell; Immunotherapy; Killer cells; Melanoma cells; IMMUNITY; GENERATION; ACTIVATION; SECRETION; MELANOMA; HMGB1; DCS;
D O I
10.1007/s10529-009-0072-8
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
To investigate the efficacy of dendritic cells and natural killer cells in the inhibition of lung metastasis, we injected dendritic cells and natural killer cells intravascularly into mice bearing B16F10 tumour melanoma cells. This efficiently inhibited tumor growth and prolonged survival. In addition, surviving mice developed a long-lasting memory response against the original tumor when re-challenged with live tumor cells. Intravenous administration of dendritic cells and natural killer cells may be a potential way to treat lung metastasis in patients.
引用
收藏
页码:1709 / 1715
页数:7
相关论文
共 50 条
  • [1] Inhibition of lung metastasis in mice by intravascular injection of dendritic cells and natural killer cells
    Hui-fang Lv
    Feng Cui
    Chang-hua Yu
    Li-li Deng
    Jing-jing Ji
    Dan Lu
    Yu Yang
    Wen-xiu Wang
    Yu-qing Xu
    Biotechnology Letters, 2009, 31 : 1709 - 1715
  • [2] Natural killer cells complot with dendritic cells
    Bielawska-Pohl, Aleksandra
    Pajtasz-Piasecka, Elzbieta
    Dus, Danuta
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2013, 67 : 192 - 200
  • [3] Natural Killer Cells and Dendritic Cells: Expanding Clinical Relevance in the Non-Small Cell Lung Cancer (NSCLC) Tumor Microenvironment
    Ahluwalia, Pankaj
    Ahluwalia, Meenakshi
    Mondal, Ashis K.
    Sahajpal, Nikhil S.
    Kota, Vamsi
    Rojiani, Mumtaz, V
    Kolhe, Ravindra
    CANCERS, 2021, 13 (16)
  • [4] Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells
    Piccioli, D
    Sbrana, S
    Melandri, E
    Valiante, NM
    JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (03) : 335 - 341
  • [5] A critical role for natural killer cells in dendritic cell-based anticancer immunotherapy
    McLellan, Alexander D.
    ONCOIMMUNOLOGY, 2014, 3 (04):
  • [6] Dendritic cells and natural killer cells: The road to a successful oncolytic virotherapy
    Ghasemi, Matin
    Abbasi, Laleh
    Naeini, Leila Ghanbari
    Kokabian, Pajman
    Fard, Najmeh Nameh Goshay
    Givtaj, Nozar
    FRONTIERS IN IMMUNOLOGY, 2023, 13
  • [7] Invariant natural killer T cells promote immunogenic maturation of lung dendritic cells in mouse models of asthma
    He, Qing
    Liu, Linlin
    Yang, Qiaoyu
    Wang, Ailing
    Chen, Shuo
    Li, Ruiyun
    Huang, Yi
    Zhang, Guqin
    Ding, Xuhong
    Yu, Hongying
    Hu, Suping
    Nie, Hanxiang
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2017, 313 (06) : L973 - L990
  • [8] Anti-CD1d treatment suppresses immunogenic maturation of lung dendritic cells dependent on lung invariant natural killer T cells in asthmatic mice
    Lin, Qibin
    Wang, Tong
    Zuo, Xiaoshu
    Ni, Haiyang
    Zhong, Jieying
    Zhan, Liying
    Cheng, Hong
    Huang, Yi
    Ding, Xuhong
    Yu, Hongying
    Nie, Hanxiang
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 124
  • [9] Miscarriage induced by adoptive transfer of dendritic cells and invariant natural killer T cells into mice
    Negishi, Yasuyuki
    Ichikawa, Tomoko
    Takeshita, Toshiyuki
    Takahashi, Hidemi
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2018, 48 (06) : 937 - 949
  • [10] Function and subsets of dendritic cells and natural killer cells were decreased in gastric cancer
    Chen, Jianping
    Yang, Jing
    Jiang, Jingting
    Zhuang, Yun
    He, Wei
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2014, 7 (11): : 8304 - 8311