Inhibition of lung metastasis in mice by intravascular injection of dendritic cells and natural killer cells

被引：1

作者：

Lv, Hui-fang ^{[1
]}

Cui, Feng ^{[1
]}

Yu, Chang-hua ^{[1
]}

Deng, Li-li ^{[1
]}

Ji, Jing-jing ^{[1
]}

Lu, Dan ^{[1
]}

Yang, Yu ^{[1
]}

Wang, Wen-xiu ^{[1
]}

Xu, Yu-qing ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Oncol, Harbin 150086, Heilongjiang, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2009年 / 31卷 / 11期

关键词：

Cancer; Cytotoxic lymphocyte; Dendritic cell; Immunotherapy; Killer cells; Melanoma cells; IMMUNITY; GENERATION; ACTIVATION; SECRETION; MELANOMA; HMGB1; DCS;

D O I：

10.1007/s10529-009-0072-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To investigate the efficacy of dendritic cells and natural killer cells in the inhibition of lung metastasis, we injected dendritic cells and natural killer cells intravascularly into mice bearing B16F10 tumour melanoma cells. This efficiently inhibited tumor growth and prolonged survival. In addition, surviving mice developed a long-lasting memory response against the original tumor when re-challenged with live tumor cells. Intravenous administration of dendritic cells and natural killer cells may be a potential way to treat lung metastasis in patients.

引用

页码：1709 / 1715

页数：7

共 14 条

[1] ACCUMULATION OF ADOPTIVELY TRANSFERRED ADHERENT, LYMPHOKINE-ACTIVATED KILLER-CELLS IN MURINE METASTASES [J].

BASSE, P ;

HERBERMAN, RB ;

NANNMARK, U ;

JOHANSSON, BR ;

HOKLAND, M ;

WASSERMAN, K ;

GOLDFARB, RH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (02) :479-488

[2] NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs [J].

Borg, C ;

Jalil, A ;

Laderach, D ;

Maruyama, K ;

Wakasugi, H ;

Charrier, S ;

Ryffel, B ;

Cambi, A ;

Figdor, C ;

Vainchenker, W ;

Galy, A ;

Caignard, A ;

Zitvogel, L .

BLOOD, 2004, 104 (10) :3267-3275

[3] Melanoma and lymphoma rejection associated with eosinophil infiltration upon intratumoral injection of dendritic and NK/LAK cells [J].

Capobianco, Annalisa ;

Manfredi, Angelo A. ;

Monno, Antonella ;

Rovere-Querini, Patrizia ;

Rugarli, Claudio .

JOURNAL OF IMMUNOTHERAPY, 2008, 31 (05) :458-465

[4] Antitumor immunity induced by tumor cells engineered to express a membrane-bound form of IL-2 [J].

Chang, MR ;

Lee, WH ;

Choi, JW ;

Park, SO ;

Paik, SG ;

Kim, YS .

EXPERIMENTAL AND MOLECULAR MEDICINE, 2005, 37 (03) :240-249

[5] The secretion of HMGB1 is required for the migration of maturing dendritic cells [J].

Dumitriu, Ingrid E. ;

Bianchi, Marco E. ;

Bacci, Monica ;

Manfredi, Angelo A. ;

Rovere-Querini, Patrizia .

JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 81 (01) :84-91

[6] Cytokine gene therapy using adenovirally transduced, tumor-seeking activated natural killer cells [J].

Goding, Stephen R. ;

Yang, Qin ;

Knudsen, Kristina B. ;

Potter, Douglas M. ;

Basse, Per H. .

HUMAN GENE THERAPY, 2007, 18 (08) :701-711

[7] Activated natural killer cell-mediated immunity is required for the inhibition of tumor metastasis by dendritic cell vaccination [J].

Kim, A ;

Noh, YW ;

Kim, KD ;

Jang, YS ;

Choe, YK ;

Lim, JS .

EXPERIMENTAL AND MOLECULAR MEDICINE, 2004, 36 (05) :428-443

[8] Next generation of immunotherapy for melanoma [J].

Kirkwood, John M. ;

Tarhini, Ahmad A. ;

Panelli, Monica C. ;

Moschos, Stergios J. ;

Zarour, Hassane M. ;

Butterfield, Lisa H. ;

Gogas, Helen J. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (20) :3445-3455

[9] Modification of the tumor microenvironment to enhance immunity [J].

Liao, Yu-Pei ;

Schaue, Dorthe ;

McBride, William H. .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2007, 12 :3576-3600

[10]

Peng LM, 1997, CANCER RES, V57, P4849

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