Domino Alkylation-Cyclization Reaction of Propargyl Bromides with Thioureas/Thiopyrimidinones: A New Facile Synthesis of 2-Aminothiazoles and 5H-Thiazolo[3,2-a]pyrimidin-5-ones

被引：47

作者：

Castagnolo, Daniele ^{[1
]}

Pagano, Mafalda ^{[1
]}

Bernardini, Martina ^{[1
]}

Botta, Maurizio ^{[1
,2
]}

机构：

[1] Univ Siena, Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy

[2] Temple Univ, Sbarro Inst Canc Res & Mol Med, Ctr Biotechnol, Coll Sci & Technol, Philadelphia, PA 19122 USA

来源：

SYNLETT | 2009年 / 13期

关键词：

domino reaction; 2-aminothiazole; thiazolopyrimidinone; microwave synthesis; antiviral agents; ONE-POT SYNTHESIS; REVERSE-TRANSCRIPTASE; ANTI-HIV-1; ACTIVITY; SUPPORTED REAGENTS; THIAZOLE SYNTHESIS; INHIBITORS; DERIVATIVES; CYCLOCONDENSATION; THIOAMIDES; SERIES;

D O I：

10.1055/s-0029-1217700

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones was developed as a domino alkylation-cyclization reaction of propargyl bromides with thioureas and thiopyrimidinones, respectively. Domino reactions were performed under microwave irradiation leading to desired compounds in a few minutes and high yields.

引用

页码：2093 / 2096

页数：4

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