Alzheimer's Disease: Biomarkers in the Genome, Blood, and Cerebrospinal Fluid

被引：81

作者：

Huynh, Rose Ann ^{[1
]}

Mohan, Chandra ^{[1
]}

机构：

[1] Univ Houston, Dept Biomed Engn, Houston, TX 77004 USA

来源：

FRONTIERS IN NEUROLOGY | 2017年 / 8卷

关键词：

Alzheimer's disease; early detection; genetic biomarkers; neurochemical biomarkers; blood-derived biomarkers; longitudinal studies; PLASMA AMYLOID-BETA; APOLIPOPROTEIN-E; COGNITIVE DECLINE; CLINICAL-TRIALS; A-BETA; PROGNOSTIC BIOMARKER; PREDICTIVE-VALUE; GENETIC RISK; TAU; DIAGNOSIS;

D O I：

10.3389/fneur.2017.00102

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that slowly destroys memory and thinking skills, resulting in behavioral changes. It is estimated that nearly 36 million are affected globally with numbers reaching 115 million by 2050. AD can only be definitively diagnosed at autopsy since its manifestations of senile plaques and neurofibrillary tangles throughout the brain cannot yet be fully captured with current imaging technologies. Current AD therapeutics have also been suboptimal. Besides identifying markers that distinguish AD from controls, there has been a recent drive to identify better biomarkers that can predict the rates of cognitive decline and neocortical amyloid burden in those who exhibit preclinical, prodromal, or clinical AD. This review covers biomarkers of three main types: genes, cerebrospinal fluid-derived, and blood-derived biomarkers. Looking ahead, cutting-edge OMICs technologies, including proteomics and metabolomics, ought to be fully tapped in order to mine even better biomarkers for AD that are more predictive.

引用

页数：15

共 121 条

[91] Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014 [J].

Schneider, L. S. ;

Mangialasche, F. ;

Andreasen, N. ;

Feldman, H. ;

Giacobini, E. ;

Jones, R. ;

Mantua, V. ;

Mecocci, P. ;

Pani, L. ;

Winblad, B. ;

Kivipelto, M. .

JOURNAL OF INTERNAL MEDICINE, 2014, 275 (03) :251-283

[92] Biological Marker Candidates of Alzheimer's Disease in Blood, Plasma, and Serum [J].

Schneider, Philine ;

Hampel, Harald ;

Buerger, Katharina .

CNS NEUROSCIENCE & THERAPEUTICS, 2009, 15 (04) :358-374

[93] The neuronal calcium sensor protein VILIP-1 is associated with amyloid plaques and extracellular tangles in Alzheimer's disease and promotes cell death and tau phosphorylation in vitro: A link between calcium sensors and Alzheimer's disease? [J].

Schnurra, I ;

Bernstein, HG ;

Riederer, P ;

Braunewell, KH .

NEUROBIOLOGY OF DISEASE, 2001, 8 (05) :900-909

[94] Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease [J].

Seshadri, Sudha ;

Fitzpatrick, Annette L. ;

Ikram, M. Arfan ;

DeStefano, Anita L. ;

Gudnason, Vilmundur ;

Boada, Merce ;

Bis, Joshua C. ;

Smith, Albert V. ;

Carassquillo, Minerva M. ;

Lambert, Jean Charles ;

Harold, Denise ;

Schrijvers, Elisabeth M. C. ;

Ramirez-Lorca, Reposo ;

Debette, Stephanie ;

Longstreth, W. T., Jr. ;

Janssens, A. Cecile J. W. ;

Pankratz, V. Shane ;

Dartigues, Jean Francois ;

Hollingworth, Paul ;

Aspelund, Thor ;

Hernandez, Isabel ;

Beiser, Alexa ;

Kuller, Lewis H. ;

Koudstaal, Peter J. ;

Dickson, Dennis W. ;

Tzourio, Christophe ;

Abraham, Richard ;

Antunez, Carmen ;

Du, Yangchun ;

Rotter, Jerome I. ;

Aulchenko, Yurii S. ;

Harris, Tamara B. ;

Petersen, Ronald C. ;

Berr, Claudine ;

Owen, Michael J. ;

Lopez-Arrieta, Jesus ;

Varadarajan, Badri N. ;

Becker, James T. ;

Rivadeneira, Fernando ;

Nalls, Michael A. ;

Graff-Radford, Neill R. ;

Campion, Dominique ;

Auerbach, Sanford ;

Rice, Kenneth ;

Hofman, Albert ;

Jonsson, Palmi V. ;

Schmidt, Helena ;

Lathrop, Mark ;

Mosley, Thomas H. ;

Au, Rhoda .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 303 (18) :1832-1840

[95] Cerebrospinal Fluid Biomarker Signature in Alzheimer's Disease Neuroimaging Initiative Subjects [J].

Shaw, Leslie M. ;

Vanderstichele, Hugo ;

Knapik-Czajka, Malgorzata ;

Clark, Christopher M. ;

Aisen, Paul S. ;

Petersen, Ronald C. ;

Blennow, Kaj ;

Soares, Holly ;

Simon, Adam ;

Lewczuk, Piotr ;

Dean, Robert ;

Siemers, Eric ;

Potter, William ;

Lee, Virginia M. -Y. ;

Trojanowski, John Q. .

ANNALS OF NEUROLOGY, 2009, 65 (04) :403-413

[96] A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42 [J].

Sleegers, Kristel ;

Bettens, Karolien ;

De Roeck, Arne ;

Van Cauwenberghe, Caroline ;

Cuyvers, Elise ;

Verheijen, Jan ;

Struyfs, Hanne ;

Van Dongen, Jasper ;

Vermeulen, Steven ;

Engelborghs, Sebastiaan ;

Vandenbulcke, Mathieu ;

Vandenberghe, Rik ;

De Deyn, Peter Paul ;

Van Broeckhoven, Christine .

ALZHEIMERS & DEMENTIA, 2015, 11 (12) :1452-1460

[97] Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain [J].

Sottejeau, Yoann ;

Bretteville, Alexis ;

Cantrelle, Francois-Xavier ;

Malmanche, Nicolas ;

Demiaute, Florie ;

Mendes, Tiago ;

Delay, Charlotte ;

Dos Alves, Harmony Alves ;

Flaig, Amandine ;

Davies, Peter ;

Dourlen, Pierre ;

Dermaut, Bart ;

Laporte, Jocelyn ;

Amouyel, Philippe ;

Lippens, Guy ;

Chapuis, Julien ;

Landrieu, Isabelle ;

Lambert, Jean-Charles .

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2015, 3 :58

[98] The Evolution of Preclinical Alzheimer's Disease: Implications for Prevention Trials [J].

Sperling, Reisa ;

Mormino, Elizabeth ;

Johnson, Keith .

NEURON, 2014, 84 (03) :608-622

[99] The A4 Study: Stopping AD Before Symptoms Begin? [J].

Sperling, Reisa A. ;

Rentz, Dorene M. ;

Johnson, Keith A. ;

Karlawish, Jason ;

Donohue, Michael ;

Salmon, David P. ;

Aisen, Paul .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (228)

[100] TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis [J].

Takahashi, Kazuya ;

Prinz, Marco ;

Stagi, Massimiliano ;

Chechneva, Olga ;

Neumann, Harald .

PLOS MEDICINE, 2007, 4 (04) :675-689

← 4 5 6 7 8 9 10 11 12 13 →