The kinetics of the removal of the N-methyltrityl (Mtt) group during the synthesis of branched peptides

被引：36

作者：

Li, D ^{[1
]}

Elbert, DL ^{[1
]}

机构：

[1] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

来源：

JOURNAL OF PEPTIDE RESEARCH | 2002年 / 60卷 / 05期

关键词：

branched peptide; deprotection; methyltrityl; Mtt; protecting groups;

D O I：

10.1034/j.1399-3011.2002.21018.x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of this short communication is to describe the reaction rate for the removal of the N-methyltrityl (Mtt) protecting group that is used in solid-phase peptide synthesis for the production of branched and cyclic peptides. The reaction rate was observed to follow zero-order kinetics, and we suggest the optimal conditions for the removal of the Mtt group in batchwise synthesis.

引用

页码：300 / 303

页数：4