Inhibition of inosine monophosphate dehydrogenase (IMPDH) by 2-[2-(Z)-fluorovinyl]inosine 5′-monophosphate

被引：13

作者：

Nair, V ^{[1
]}

Kamboj, RC ^{[1
]}

机构：

[1] Univ Georgia, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(02)01053-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inosine 5'-monophosphate dehydrogenase (IMPDH: EC 1.1.1.205) isolated from Esherichia coli 133 cells was strongly T inhibited by 2-[2-(Z)-fluorovinyl]inosine 5'-monophosphate (2-FVIMP). Inhibition of IMPDH appears to be irreversible with k(inact) and K-i values of 0.0269 s(-1) an IMPDH, respectively. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：645 / 647

页数：3

共 50 条

[31] Mechanistic study of inosine monophosphate dehydrogenase [J].

Braun-Sand, Sonja ;

Anciaux, Desiree ;

Cook, Angela .

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 :347-347

[32] "Rods and Rings" inclusions formed by Inosine-5′-monophosphate dehydrogenase 2 [J].

Juda, P. ;

Smigova, J. ;

Raska, I. .

FEBS JOURNAL, 2014, 281 :705-705

[33] INTERACTIONS OF NI-2+ WITH INOSINE AND INOSINE 5'-MONOPHOSPHATE - EQUILIBRIA AND DYNAMICS [J].

NAGASAWA, A ;

DIEBLER, H .

JOURNAL OF PHYSICAL CHEMISTRY, 1981, 85 (23) :3523-3528

[34] Species-specific inhibition of inosine 5′-monophosphate dehydrogenase by mycophenolic acid [J].

Digits, JA ;

Hedstrom, L .

BIOCHEMISTRY, 1999, 38 (46) :15388-15397

[35] INOSINE 5′-MONOPHOSPHATE DEHYDROGENASE (IMPDH) ACTIVITY IN PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) IN HEALTHY CHILDREN [J].

Rother, A. ;

Vitt, E. ;

Glander, P. ;

Kiesewalter, S. ;

Budde, K. ;

Armstrong, V. W. ;

Oellerich, M. ;

Toenshoff, B. ;

Weber, L. T. .

PEDIATRIC NEPHROLOGY, 2009, 24 (09) :1877-1877

[36] The use of inosine 5′-monophosphate dehydrogenase (IMPDH) in the development of a new liquid homogeneous enzyme immunoassay technology [J].

Dorn, AR ;

Mountain, LD ;

Ghoshal, M ;

Hui, RA ;

Klinedinst, LK ;

Rugaber, JE ;

Schamerloh, AF ;

Salamone, SJ .

CLINICAL CHEMISTRY, 2001, 47 (10) :1921-1922

[37] MECHANISM OF FORMATION OF INOSINE MONOPHOSPHATE IN HUMAN ERYTHROCYTES .2. SYNTHESIS OF INOSINE MONOPHOSPHATE FROM INOSINE UPON PHOSPHOROLYTIC DECOMPOSITION OF INOSINE [J].

BANASCHA.H .

ACTA BIOLOGICA ET MEDICA GERMANICA, 1966, 17 (03) :261-&

[38] INHIBITION OF INOSINE MONOPHOSPHATE-DEHYDROGENASE BY THYROID HORMONES IN VITRO [J].

ALMUDHAF.S ;

ACKERMAN, CJ .

ENDOCRINOLOGY, 1968, 82 (05) :912-&

[39] Inosine 5′-Monophosphate Dehydrogenase (IMPDH) activity in peripheral blood mononuclear cells (PBMCs) in healthy children [J].

Rother, A. ;

Vitt, E. ;

Glander, P. ;

Kiesewalter, S. ;

Budde, C. ;

Armstrong, V. ;

Oellerich, M. ;

Toenshoff, B. ;

Weber, L. T. .

PEDIATRIC NEPHROLOGY, 2009, 24 (04) :910-910

[40] Effect of mycophenolic acid on inosine monophosphate dehydrogenase (IMPDH) activity in liver transplant patients [J].

Neuberger, M. ;

Sommerer, C. ;

Boehnisch, S. ;

Metzendorf, N. ;

Mehrabi, A. ;

Stremmel, W. ;

Gotthardt, D. ;

Zeier, M. ;

Weiss, K. H. ;

Rupp, C. .

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2020, 44 (04) :543-550

← 1 2 3 4 5 →