Inhibition of inosine monophosphate dehydrogenase (IMPDH) by 2-[2-(Z)-fluorovinyl]inosine 5′-monophosphate

被引：13

作者：

Nair, V ^{[1
]}

Kamboj, RC ^{[1
]}

机构：

[1] Univ Georgia, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(02)01053-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Inosine 5'-monophosphate dehydrogenase (IMPDH: EC 1.1.1.205) isolated from Esherichia coli 133 cells was strongly T inhibited by 2-[2-(Z)-fluorovinyl]inosine 5'-monophosphate (2-FVIMP). Inhibition of IMPDH appears to be irreversible with k(inact) and K-i values of 0.0269 s(-1) an IMPDH, respectively. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：645 / 647

页数：3

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