Asymmetric hydrogenation of cyclic alpha,beta-unsaturated ketones to chiral allylic alcohols

被引：0

作者：

Ohkuma, T ^{[1
]}

Ikehira, H ^{[1
]}

Ikariya, T ^{[1
]}

Noyori, R ^{[1
]}

机构：

[1] RES DEV CORP JAPAN, ERATO, MOL CATALYSIS PROJECT, TOYOTA 47003, JAPAN

来源：

SYNLETT | 1997年 / 05期

关键词：

asymmetric hydrogenation; BINAP; chiral allylic alcohol; chiral 1,2-diamine; alpha; beta-unsaturated ketone;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Ru(II)-BINAP-1,2-diphenylethylenediamine combined catalyst system effects asymmetric hydrogenation of certain cyclic enones in 2-propanol containing KOH with a substrate/catalyst molar ratio of 250 to 2500. The hydrogenation occurs selectively at the C=O function with excellent enantio- or diastereoselectivity.

引用

页码：467 / +