Inflammation A driving force speeds cancer metastasis

被引：266
作者：
Wu, Yadi [2 ,3 ]
Zhou, Binhua P. [1 ,3 ]
机构：
[1] Univ Kentucky, Sch Med, Dept Mol & Cellular Biochem, Lexington, KY 40536 USA
[2] Univ Kentucky, Sch Med, Dept Mol & Biomed Pharmacol, Lexington, KY 40536 USA
[3] Univ Kentucky, Sch Med, Lucille P Markey Canc Ctr, Lexington, KY 40536 USA
来源：
CELL CYCLE | 2009年 / 8卷 / 20期
关键词：
inflammation; epithelial-mesenchymal transition; metastasis; NF-KAPPA-B; EPITHELIAL-MESENCHYMAL TRANSITION; CHEMOKINE RECEPTOR CXCR4; BREAST-CANCER; TGF-BETA; TUMOR PROGRESSION; SUPPRESSOR-CELLS; STAT3; ACTIVATION; GROWTH-FACTOR; PANCREATIC-CANCER;
D O I：
10.4161/cc.8.20.9699
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
It has been increasingly recognized that tumor microenvironment plays an important role in carcinogenesis. Inflammatory component is present and contributes to tumor proliferation, angiogenesis, metastasis and resistance to hormonal and chemotherapy. This review highlights the role of inflammation in the tumor metastasis. We focus on the function of proinflammatory factors, particularly cytokines during tumor metastasis. Understanding of the mechanisms by which inflammation contributes to metastasis will lead to innovative approach for treating cancer.
引用
收藏
页码：3267 / 3273
页数：7
相关论文
共 89 条
  • [1] Metastasis signatures: genes regulating tumor-microenvironment interactions predict metastatic behavior
    Albini, Adriana
    Mirisola, Valentina
    Pfeffer, Ulrich
    [J]. CANCER AND METASTASIS REVIEWS, 2008, 27 (01) : 75 - 83
  • [2] Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer
    Almand, B
    Clark, JI
    Nikitina, E
    van Beynen, J
    English, NR
    Knight, SC
    Carbone, DP
    Gabrilovich, DI
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 166 (01) : 678 - 689
  • [3] Effects of micro-environment- and malignant cell-derived interleukin-1 in carcinogenesis, tumour invasiveness and tumour-host interactions
    Apte, RN
    Krelin, Y
    Song, XP
    Dotan, S
    Recih, E
    Elkabets, M
    Carmi, Y
    Dvorkin, T
    White, RM
    Gayvoronsky, L
    Segal, S
    Voronou, E
    [J]. EUROPEAN JOURNAL OF CANCER, 2006, 42 (06) : 751 - 759
  • [4] Expression of both TNF-α receptor subtypes is essential for optimal skin tumour development
    Arnott, CH
    Scott, KA
    Moore, RJ
    Robinson, SC
    Thompson, RG
    Balkwill, FR
    [J]. ONCOGENE, 2004, 23 (10) : 1902 - 1910
  • [5] Inflammation and cancer: back to Virchow?
    Balkwill, F
    Mantovani, A
    [J]. LANCET, 2001, 357 (9255) : 539 - 545
  • [6] gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis
    Bollrath, Julia
    Phesse, Toby J.
    von Burstin, Vivian A.
    Putoczki, Tracy
    Bennecke, Moritz
    Bateman, Trudie
    Nebelsiek, Tim
    Lundgren-May, Therese
    Canli, Oezge
    Schwitalla, Sarah
    Matthews, Vance
    Schmid, Roland M.
    Kirchner, Thomas
    Arkan, Melek C.
    Ernst, Matthias
    Greten, Florian R.
    [J]. CANCER CELL, 2009, 15 (02) : 91 - 102
  • [7] Genes that mediate breast cancer metastasis to the brain
    Bos, Paula D.
    Zhang, Xiang H. -F.
    Nadal, Cristina
    Shu, Weiping
    Gomis, Roger R.
    Nguyen, Don X.
    Minn, Andy J.
    van de Vijver, Marc J.
    Gerald, William L.
    Foekens, John A.
    Massague, Joan
    [J]. NATURE, 2009, 459 (7249) : 1005 - U137
  • [8] Inflammation and Cancer: IL-6 and STAT3 Complete the Link
    Bromberg, Jacqueline
    Wang, Timothy C.
    [J]. CANCER CELL, 2009, 15 (02) : 79 - 80
  • [9] BRUYERE F, 2009, UROL ONCOL
  • [10] Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
    Bunt, Stephanie K.
    Yang, Linglin
    Sinha, Pratima
    Clements, Virginia K.
    Leips, Jeff
    Ostrand-Rosenberg, Suzanne
    [J]. CANCER RESEARCH, 2007, 67 (20) : 10019 - 10026
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