Pretreatment with empty liposomes attenuates the immunopathology of invasive pulmonary aspergillosis in corticosteroid-immunosuppressed mice

被引：37

作者：

Lewis, Russell E.

Chamilos, Georgios

Prince, Randall A.

Kontoyiannis, Dimitrios P.

机构：

[1] Univ Houston, Coll Pharm, Dept Clin Sci & Adm, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 03期

关键词：

D O I：

10.1128/AAC.01268-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a nonneutropenic murine model of invasive pulmonary aspergillosis, pretreatment with empty liposomes (E-lipo) was nearly as effective as 10 mg/kg of body weight liposomal amphotericin B and superior to I mg/kg amphotericin B deoxycholate. The beneficial immunomodulatory properties of E-lipo appear to compensate for their lack of direct antifungal activity.

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收藏

页码：1078 / 1081

页数：4

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